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Stroke Investigation Network - Understanding Mechanisms


SIGNUM is an observational study that looks to recruit patients from stroke services such as Rehabilitation Facilities, GP’s and TIA clinics, as well as any other service that looks after stroke patients. SIGNUM will also look to recruit patients at risk of stroke – for example those with arterio-venous malformations. The main focus of SIGNUM is to collect genetic and biomarker data linked to data recorded as part of a patient’s routine clinical care.

What is involved?

  • A blood sample will be taken. This will be stored to measure circulating markers and DNA that will be assessed to see if they can help identify causes of stroke which can then also be targeted in the future to reduce the risk of stroke.

  • In addition to these blood tests we will use the clinical information that has been collected about you and your health for as part of your care or that which contributes to national audit data in stroke. This will include clinical findings from the doctors, nurses, therapists and other health professionals that are involved with your care either in your written or electronic record, results of routine blood tests, ECG’s and any imaging that is XRay’s, ultrasound scans, CT scans or MRI scans). You do not need to do anything for this, we can simply collect this information from your record with your permission.

  • Some individuals will need surgery to unblock a narrowing in one of the vessels in the neck that supplies the brain with blood, and it is thought that this is the cause of stroke. If you are one of these individuals, we would also like to ask you if at the time of your operation, any tissue taken away at that time we may use for research. We are requesting tissue that would be surplus to requirements of diagnosis and would normally be discarded. If we can store and use for research, linking with the patients other information this will help us understand the mechanisms of how this narrowing forms in the first place.



To take part in this study you must meet the following inclusion criteria:


    Adults over the age of 18, who present to or are referred to the stroke services.



    Also, individuals with vascular malformations whoa re at risk of stroke, or such malformations may have contributed to their stroke, in particular, haemorrhagic stroke.


If you would like to take part or find out more please contact the study lead:

Study Contact: Qi Zheng


Tel:     023 8047 5258