skip to main content



A randomised, double blind, placebo controlled parallel group trial of vitamin D supplementation compared to placebo in people presenting with their First Episode of psychosis (DFEND). This study aims to explore how the addition of vitamin D supplements to standard treatments can help people recover after having their first episode of psychosis. 

Participants of the study will continue to receive their standard treatments for psychosis. Half of the participants will be randomly allocated to receive a vitamin D supplement while the other half will receive a placebo treatment. Treatment will last for 6 months with a short home visit each month for the duration of the study.
To take part you must meet the following criteria:
  • Aged between 18-45 years old

  • Diagnosis of psychosis

  • Willing to refrain from taking multivitamins or non-study Vitamin D supplements including cod liver oil



You cannot take part in this study if:

  • You have a known intolerance of Vitamin D2 or D3 or known allergy to any the trial medication

  • You are currently taking vitamin D supplements at a dose exceeding 400IU/day

  • You have a known current anaemia, sickle cell anaemia and beta or alpha thalassemia

If you would like to take part or want more information please contact the study lead:


Study Contact: Joanne McCarthy


Tel: 02380 475943

Page Comments