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SIREN study

SIREN (Sarscov2 Immunity & Reinfection EvaluatioN):
The impact of detectable anti SARS-COV2 antibody on the incidence of COVID-19 in healthcare workers


Southern Health R&D Department is working with Public Health England on an urgent public health Covid-19 (SARS-CoV2) research. The overall aim of the SIREN study is to determine if prior infection on Covid-19 provides future immunity to re-infection. The data collected will also help to inform on the effectiveness of any vaccine administered. 

UPDATE (February 2021):

The study is now closed for participant recruitment. Thank you for your interest in the study.


  • A short initial online questionnaire.
  • A brief online follow-up questionnaire every two weeks.
  • A self-administered anterior nasal swab every two weeks (this will be in addition to the Trust’s Lateral Flow Device testing).
  • A small blood sample to test serum antibody status every four weeks.

Follow-up questionnaires and test results (swab and antibody) will be sent to the participant via registered mobile phone or email.

To ensure the long term immunity status, the follow-up questionnaires and tests will continue for 12 months.

Are you……..

  • A Southern Health NHS Foundation Trust staff member who works in a clinical setting where patients are present? (NOT remote working at home)?

This includes all staff members who work on a site where patients are present – you do not need to be patient facing.  You must work in the healthcare organisation but do not need to be employed by Southern Health (working student healthcare workers or those employed by contracting organisations are eligible).

  • Able to provide written consent (incorporated in the initial online questionnaire)
  • Able to remain engaged with follow-up for 12 months, even if you move to another healthcare organisation.
  • Able to attend Lymington New Forest Hospital (Mondays), Gosport War Memorial Hospital (Tuesdays) or Moorgreen Hospital (Wednesdays) regularly for swab and blood sample collection.   


For full study details:

Please follow the links to:


Please email shft.siren@nhs.net or call the research team 07920 833165 with your phone number, job role and your preferred study site.

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