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Screening of Target Genes (Asthma)

Screening of Target Genes (Asthma)

Screening of target genes for polymorphic variation which may alter treatment response for airway treatment targets. The aims of the study are to define the extent of polymorphic variation in genes whose products are, or may be, primary targets for treatment of patients with asthma, and to identify if this genetic variation contributes to disease severity or treatment response. 

A 20- 30 minute appointment which will include:
  • Conducting a breathing test known as spirometry and peak flows.

  • Collecting a blood sample.

  • Asking you a few questions about your asthma and medications you take. 

To take part you must meet the following criteria:
  • Have asthma for more than one year.

  • Be prescribed asthma medication.

  • Aged 16 to 60.

  • Of European descent.


NOTE:You cannot take part if:

  • Known highly transmissible or serious blood-borne infection that would render the whole blood and saliva samples a serious biohazard. This includes Hepatitis B, Hepatitis C, and HIV. If the individual gaining consent or performing phlebotomy has any concerns in this regard they should contact one of the study investigators.

  • Anyone unable to comprehend the study and provide informed consent, e.g. insufficient command of English in the absence of someone to adequately interpret.

  • Smoking history of more than ten pack years.

  • Known lung, chest wall, neuromuscular, or cardiac disease or abnormality that would confound symptom scores and Spirometry.

If you would like to take part or want more information please contact the study lead:

 

Study Contact: Qi Zheng

Email: Qi.Zheng@nhs.net

Tel: 023 8047 5258

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